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They all return to Nya's apartment where Dolores has managed to make it safely. Meanwhile, at the NFFA headquarters, Updale becomes suspicious of a sudden increase in murder, along with the presence of masked participants.

She reviews the video footage of the Purge and notices vans full of masked killers arriving. Much to her horror, she finds out that the said masked killers are trained mercenary groups killing multiple civilians.

Sabian explains that he sent the mercenaries to make the experiment look successful, and eventually to help balance the wealth disequilibrium amongst the rich and the poor.

Updale protests this tampering, realizing that the NFFA only wants to eradicate the poor to save the expense of social programs.

Knowing that his corruption has been exposed, Sabian has Updale taken away and killed, and erases all footage of the event.

Capital A and his crew go to Dmitri's office to thank Anna and Elsa, but Dmitri and his gang kill them all. Dmitri and his gang escape through the streets, until unknown assailants attack them.

Dmitri kills them all and discovers they are mercenaries. Realizing they were sent by the NFFA, who had also dumped weapons into the neighborhood to provoke participation, Dmitri and his crew decide to take a stand against them and protect the neighborhood.

After saving local shop owner and friend Freddy and his associates, they go to Nya's apartment building to try and save her and her friends, but NFFA drones shoot and kill most of Dmitri's gang.

Dmitri calls Nya and warns her of the mercenaries' invasion, but he is coming to help her. Dmitri successfully kills a number of mercenaries and helped Nya's group to hide in a safe space.

The mercenaries are about to shoot a rocket-propelled grenade into the apartments when a deranged Skeletor arrives and kills some mercenaries before he himself is killed.

Dmitri grabs a piece of plastic explosive , throws it and shoots it repeatedly until it explodes, killing the remaining mercenaries.

As sirens sound the end of the Purge, a wounded Dmitri is hailed as a hero, and he states that the survivors must somehow fight back. During the end credits, Sabian reads a statement calling this experimental Purge a success, and that a nationwide Purge may begin as soon as the following year.

A mid-credits scene leads into the events of the other films, and directly ties into The Purge television series.

In September , James DeMonaco , the creator of the franchise, said that the fourth film, a follow-up to 's The Purge: Election Year , would be a prequel to the trilogy, showing how the United States came to the point of accepting the Purge Night.

On September 19, , newcomers Y'lan Noel and Lex Scott Davis were cast in the film as the lead characters, and the setting was announced as Staten Island.

Principal photography began in mid-September in Buffalo, New York. Filming wrapped on November 8, Kevin Lax composed the score for the film, replacing Nathan Whitehead.

Back Lot Music released the soundtrack. The website's critical consensus reads, " The First Purge should satisfy fans of the franchise and filmgoers in the mood for violent vicarious thrills, even if its subtextual reach exceeds its grasp.

From Wikipedia, the free encyclopedia. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

This article has been cited by other articles in PMC. Abstract The influenza virus IV is known to be a resistant virus with frequent mutations, causing severe respiratory diseases in the upper respiratory system.

Open in a separate window. Figure 1. In Vitro Study Statins represent one of the most widely prescribed drugs in the world; therefore, identifying their capacity to reduce influenza virus mortality and morbidity during a pandemic is a matter of public health importance.

Animal Study Selected animal studies have further recommended a protective role for statin drugs against acute lung injury; however, results have been confounding.

Human Study Despite contradictory reports, several retrospective observational studies have identified a connection between statin use and reduction of influenza virus morbidity in humans; however, considerable variability in timing and duration of drug administration among participants may restrict the results of these studies [ 25 , 26 , 32 , 63 ].

Table 1 Human studies on the efficacy of using statins in acute respiratory patients. Reference Summary of the study Conclusions Frost et al.

Kwong et al. No considerable reduction in morbidity and mortality of influenza has been observed in statin-treated patients.

Fleming et al. No beneficiary effects of statins on respiratory diseases have been observed. However, there was a kind of synergistic relation between statins and influenza vaccines.

Carrillo-Esper et al. Viasus et al. None of the therapies corticosteroids, macrolides, and statins were found effective to reduce the risk of severe disease.

Makris et al. This study evidenced that pravastatin may ameliorate the frequency of viral pneumonia.

Yende et al. Only a modest change in circulating biomarkers has been observed in statin-treated patients. Statins may have beneficiary effects on reducing mortality in hospitalized influenza patients.

Papazian et al. The result of this study does not support positive effects of simvastatin against ventilator associated pneumonia patients.

Kruger et al. This cohort study showed that continuation of atorvastatin is associated with survival improvement.

Conclusion Influenza-related illnesses are acute diseases that affect most of the human population, with various outcomes ranging from impaired quality of life to fatal infections.

Acknowledgments This study was funded by Grant no. Conflict of Interests The authors declare that there is no conflict of interests regarding the publication of this paper.

References 1. Armstrong E. Pharmacology of cholesterol and lipoprotein metabolism; pp. Endo A. Journal of Lipid Research.

Darwish I. Immunomodulatory therapy for severe influenza. Expert Review of Anti-Infective Therapy. Sun X. Role for influenza virus envelope cholesterol in virus entry and infection.

Journal of Virology. Goldstein J. Regulation of the mevalonate pathway. Blanco-Colio L. Anti-inflammatory and immunomodulatory effects of statins.

Kidney International. Laufs U. Suppression of endothelial nitric oxide production after withdrawal of statin treatment is mediated by negative feedback regulation of rho GTPase gene transcription.

Casey P. Liao J. Pleiotropic effects of statins. Annual Review of Pharmacology and Toxicology. Terblanche M.

Statins and sepsis: multiple modifications at multiple levels. The Lancet Infectious Diseases. Alexeeff S. Statin use reduces decline in lung function: VA normative aging study.

Mehrbod P. Statins reduce the expression of proinflammatory cytokines in influenza A virus infected CrFK cells.

Acta Virologica. Watts K. Simvastatin inhibits growth factor expression and modulates profibrogenic markers in lung fibroblasts.

Lee C. European Respiratory Journal. Blanc M. Host defense against viral infection involves interferon mediated down-regulation of sterol biosynthesis.

PLoS Biology. Fedson D. Pandemic influenza: a potential role for statins in treatment and prophylaxis. Clinical Infectious Diseases.

Statins, bugs and prophylaxis: intriguing possibilities. Critical Care. Campagnolo E. Fatal pandemic H1N1 influenza A virus infection in a pennsylvania domestic cat.

Zoonoses and Public Health. Garten R. George K. Antigenic and genetic characteristics of swine-origin A H1N1 influenza viruses circulating in humans.

Fatal outcome of human influenza A H5N1 is associated with high viral load and hypercytokinemia. Nature Medicine. Lippi G.

Influenza and cardiovascular disease: does swine-origin, H1N1 flu virus represent a risk factor, an acute trigger, or both?

Seminars in Thrombosis and Hemostasis. Cheung C. Induction of proinflammatory cytokines in human macrophages by influenza A H5N1 viruses: a mechanism for the unusual severity of human disease?

The Lancet. Lipatov A. Journal of General Virology. Osterholm M. Preparing for the next pandemic. New England Journal of Medicine.

Frost F. Influenza and COPD mortality protection as pleiotropic, dose-dependent effects of statins. Kwong J. Influenza morbidity and mortality in elderly patients receiving statins: a cohort study.

Fleming D. An assessment of the effect of statin use on the incidence of acute respiratory infections in England during winters — to — Epidemiology and Infection.

Carrillo-Esper R. Experience in the management of the severe form of human influenza A H1N1 pneumonia in an intensive care unit.

Cirugia y Cirujanos. Viasus D. Effect of immunomodulatory therapies in patients with pandemic influenza A H1N1 complicated by pneumonia.

Journal of Infection. Makris D. Effect of pravastatin on the frequency of ventilator-associated pneumonia and on intensive care unit mortality: open-label, randomized study.

Critical Care Medicine. Yende S. Understanding the potential role of statins in pneumonia and sepsis.

Vandermeer M. Association between use of statins and mortality among patients hospitalized with laboratory-confirmed influenza virus infections: a multistate study.

Journal of Infectious Diseases. Papazian L. Effect of statin therapy on mortality in patients with ventilator-associated pneumonia: a randomized clinical trial.

Journal of the American Medical Association. Kruger P. Allied Singapore Axis Singapore. Broome Darwin. Pearl Harbor Unalaska.

Acre Haifa Jaffa Tel Aviv. Fort Lamy. Hidden categories: CS1 errors: missing periodical Wikipedia articles needing clarification from February Wikipedia articles needing clarification from May Commons category link is on Wikidata.

Namespaces Article Talk. Views Read Edit View history. Help Community portal Recent changes Upload file. Wikimedia Commons. Download as PDF Printable version.

Smaller Bremen attacks are made on the following two nights. Heavy bombing raids were conducted on Hamburg, Bremen and Berlin. Some of the aircraft attacking alternative targets reached Hamburg, which reports 11 fires and casualties of 5 dead and 12 injured.

Following a Hamburg raid , Bremen reports a load of incendiaries dropped very accurately on the Bremer Vulkan shipyard where 4 U-boats and several surrounding buildings were damaged by fire.

Bremen recorded this as a heavy attack, the results of which exceeded all previous raids. Housing areas were heavily hit with 6 streets affected by serious fires.

Damage to the U-boat construction yards Valentin submarine pens and the Focke-Wulf factory is described as 'of no importance' but there were hits in the harbour area which damaged a pier, some warehouses and the destroyer Z Using every available aircraft in RAF Bomber Command and some of other commands, a thousand-bomber raid was mounted against Bremen.

Those of No. The limited success was entirely due to the use of GEE , which enabled the leading crews to start marker fires through the cloud cover.

At the Focke-Wulf factory, an assembly shop was completely flattened, 6 buildings were seriously damaged and 11 buildings lightly so.

The Atlas Werke , the Bremer Vulkan shipyard, the Norddeutsche Hütte , the Korff refinery, and two large dockside warehouses were also damaged.

This time, the heaviest casualties were suffered by the OTUs of No. Bremen records that two of the large firms hit in the recent Thousand raid - the Atlas Werke and the Korff refinery - were damaged again, as well as several smaller firms and dockside warehouses.

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